دانلود Diabetes mellitus and cognitive impairments

Abstract

There is strong evidence that diabetes mellitus increases the  risk  of  cognitive  impairment  and  dementia.  Insulin signaling  dysregulation  and  small  vessel  disease  in the  base  of  diabetes  may  be  important  contributing factors  in  Alzheimer’s  disease  and  vascular  dementia pathogenesis,  respectively.  Optimal  glycemic  control  in type 1 diabetes and identification of diabetic risk factors and  prophylactic  approach  in  type  2  diabetes  are  very important  in  the  prevention  of  cognitive  complications.  In addition, hypoglycemic attacks in children and elderly should  be  avoided.  Anti-diabetic  medications  especially Insulin may have a role in the management of cognitive dysfunction  and  dementia  but  further  investigation  is needed to validate these findings.