دانلود مقاله ترجمه شده مدل سازی شبکه های تنظیمی(تنظیم کننده) بیولوژیکی با شبکه پتری

The complexity of biological regulatory networks often defies the intuition of the biologist and calls for the development of proper mathematical methods to model their structures and to delineate their dynamical properties. One qualitative approach consists in modeling regulatory networks in terms of logical equations (using either Boolean or multi-level discretisations). The

Petri Net (PN) formalism offers a complementary framework to analyze the dynamical behavior of large systems, either from a qualitative or from a quantitative point of view

Our proposal consists in articulating the logical approach with the PN formalism. In a previous work, we have already defined a systematic re-writing of Boolean regulatory models into a standard PN formalism. In this paper, we propose a rigorous and systematic mapping of multi-level logical regulatory models into specific standard Petri nets, called Multi-level Regulatory Petri Nets (MRPNs). We further propose some reduction strategies. Consequently, the resulting models become amenable to the algebraic and computational analyses used by the PN community

To illustrate our approach, we apply it to a multi-level logical model of the genetic switch controlling the lysis-lysogeny decision in the lambda bacteriophage

1. Introduction

2. Logical regulatory graphs

3. Multi-level regulatory Petri nets

4. Multi-level Regulatory Petri net modelling of the genetic regulatory network controlling the lysis-lysogeny decision in

the lambda bacteriophage