دانلود MicroRNAs and spermatogenesis

ترجمه فارسی MicroRNAs and spermatogenesis
قیمت : 315,000 ریال
شناسه محصول : 2009252
نویسنده/ناشر/نام مجله : Kotaja, N. (2014). MicroRNAs and spermatogenesis. Fertility and sterility
سال انتشار: 2014
تعداد صفحات انگليسي : 11
نوع فایل های ضمیمه : Pdf+Word
حجم فایل : 327 Kb
کلمه عبور همه فایلها : www.daneshgahi.com
عنوان انگليسي : MicroRNAs and spermatogenesis

چکیده

Abstract

In mammals, male gametes are produced inside the testis by spermatogenesis, which has three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid differentiation of spermatids. The genome of male germ cells is actively transcribed to produce phase-specific gene expression patterns. Male germ cells have a complex transcriptome. In addition to protein-coding messenger RNAs, many noncoding RNAs, including microRNAs (miRNAs), are produced. The miRNAs are important regulators of gene expression. They function mainly post-transcriptionally to control the stability or translation of their target messenger RNAs. The miRNAs are expressed in a cell-specific manner during spermatogenesis to participate in the control of each step of male germ cell differentiation. Genetically modified mouse models have demonstrated the importance of miRNA pathways for normal spermatogenesis, and functional studies have been designed to dissect the roles of specific miRNAs in distinct cell types. Clinical studies have exploited the well-defined expression profiles of miRNAs, and human spermatozoal or seminal plasma miRNAs have been explored as potential biomarkers for male factor infertility. This review article discusses the current findings that support the central role of miRNAs in the regulation of spermatogenesis and male fertility.

Keywords: Spermatogenesis germ cells miRNAs Dicer noncoding RNAs
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