دانلود Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

ترجمه فارسی Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
قیمت : 365,000 ریال
شناسه محصول : 2009244
نویسنده/ناشر/نام مجله : Nature Reviews Drug Discovery
سال انتشار: 2017
تعداد صفحات انگليسي : 25
نوع فایل های ضمیمه : pdf+word
حجم فایل : 964 Kb
کلمه عبور همه فایلها : www.daneshgahi.com
عنوان انگليسي : Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

چکیده

Abstract

Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic.

Keywords: autophagy
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