دانلود Use of nanocrystalline ZnO as an efficient and reusable catalyst for a one- pot, three-component synthesis of 6-chloro- and 5,7-dichloro-4-hydroxy-3- [aryl (piperidin-1-yl)methyl]quinolin-2(1H)-ones in water

Abstract

A  one-pot,  green,  efficient  and  facile  procedure  was  applied  for  the  preparation  of  a  series  of  4-hydroxy-3-[aryl(piperidin-1-yl)methyl]quinolin-2(1H)-ones via  the  reaction  of  6-chloro-4-  hydroxyquinoline-2(1H)-one 1  and/or  5,7-dichloro-4-hydroxyquinoline-2(1H)-one 2, piperidine and aromatic aldehydes in water in the presence of nanocrystalline ZnO under reflux conditions. The desired products were obtained  in  satisfactory  yields.  The  nanocrystalline  ZnO  can  be  separated  and  reused  at  least  up  to  three  times  with  almost  the  same  catalytic activity.