دانلود Mathematical modelling for trajectories of magnetic nanoparticles in a blood vessel under magnetic field

دانلود مقاله Mathematical modelling for trajectories of magnetic nanoparticles in a blood vessel under magnetic field
قیمت : 275,000 ریال
شناسه محصول : 2009374
نویسنده/ناشر/نام مجله : ELSEVIER, Journal of Magnetism and Magnetic Materials
سال انتشار: 2015
تعداد صفحات انگليسي : 6
نوع فایل های ضمیمه : pdf+word
حجم فایل : 2 Mb
کلمه عبور همه فایلها : www.daneshgahi.com
عنوان انگليسي : Mathematical modelling for trajectories of magnetic nanoparticles in a blood vessel under magnetic field

چکیده

Abstract

A mathematical model is developed to describe the trajectories of a cluster of magnetic nanoparticles in a blood vessel for the application of magnetic drug targeting (MDT). The magnetic nanoparticles are injected into a blood vessel upstream from a malignant tissue and are captured at the tumour site with help of an applied magnetic field. The applied field is produced by a rare earth cylindrical magnet positioned outside the body. All forces expected to significantly affect the transport of nanoparticles were incorporated, including magnetization force, drag force and buoyancy force. The results show that particles are slow down and captured under the influence of magnetic force, which is responsible to attract the magnetic particles towards the magnet. It is optimized that all particles are captured either before or at the centre of the magnet (z≤0) when blood vessel is very close proximity to the magnet (d=2.5 cm). However, as the distance between blood vessel and magnet (d) increases (above 4.5 cm), the magnetic nanoparticles particles become free and they flow away down the blood vessel. Further, the present model results are validated by the simulations performed using the finite element based COMSOL software.

 

Keywords: Magnetic nanoparticles Magnetic drug targeting Particle trajectory
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