دانلود Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema

Background: Chronic obstructive pulmonary disease is a smoking-related disease, and is categorized into the emphysema and airway dominant phenotypes
قیمت : 315,000 ریال
شناسه محصول : 2009268
نویسنده/ناشر/نام مجله : Anticancer research, international journal of cancer research and treatment
سال انتشار: 2017
تعداد صفحات انگليسي : 7
نوع فایل های ضمیمه : pdf+word
حجم فایل : 141 Kb
کلمه عبور همه فایلها : www.daneshgahi.com
عنوان انگليسي : Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema

چکیده

Abstract

Background: Chronic obstructive pulmonary disease is a smoking-related disease, and is categorized into the emphysema and airway dominant phenotypes. We examined the relationship between emphysematous changes and epidermal growth factor receptor (EGFR) mutation status in patients with lung adenocarcinoma. Patients and Methods: The medical records for 250 patients with lung adenocarcinoma were retrospectively reviewed. All patients were categorized into the emphysema or non-emphysema group. Results: Wild-type EGFR was detected in 136 (54%) and mutant EGFR in 48 (19%). Emphysematous changes were observed in 87 (36%) patients. EGFR mutation was highly frequent in the non-emphysema group (p=0.0014). Multivariate  logistic  regression  analysis  showed  that emphysema was an independent risk factor for reduced frequency of EGFR mutation (Odds Ratio=3.47, p=0.005). Conclusion: Our data showed a relationship between emphysematous changes and EGFR mutation status. There might be mutually exclusive genetic risk factors for carcinogenesis and development of emphysematous changes.

Keywords: Epidermal growth factor receptor (EGFR) EGFR mutation pulmonary emphysema
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