دانلود The interplay of epigenetic marks during stem cell differentiation and development

ترجمه فارسی مقاله The interplay of epigenetic marks during stem cell differentiation and development
قیمت : 365,000 ریال
شناسه محصول : 2009254
نویسنده/ناشر/نام مجله : Nature Reviews Genetics
سال انتشار: 2017
تعداد صفحات انگليسي : 16
نوع فایل های ضمیمه : Pdf+Word
حجم فایل : 1 Mb
کلمه عبور همه فایلها : www.daneshgahi.com
عنوان انگليسي : The interplay of epigenetic marks during stem cell differentiation and development

چکیده

Abstract

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly reshaped during early development and differentiation. Epigenetic modification of chromatin provides the necessary plasticity for cells to respond to environmental and positional cues, and enables the maintenance of acquired information without changing the DNA sequence. The mechanisms involve, among others, chemical modifications of chromatin, changes in chromatin constituents and reconfiguration of chromatin interactions and 3D structure. New advances in genome-wide technologies have paved the way towards an integrative view of epigenome dynamics during cell state transitions, and recent findings in embryonic stem cells highlight how the interplay between different epigenetic layers reshapes the transcriptional landscape.

Keywords: Genomic imprints Epigenome
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