دانلود Synthesis of Buprenorphine from Oripavine via N-Demethylation of Oripavine Quaternary Salts
ترجمه مقاله Synthesis of Buprenorphine from Oripavine via N-Demethylation of Oripavine Quaternary Salts
قیمت :
1,100,000 ریال
شناسه محصول :
2007935
نویسنده/ناشر/نام مجله :
The Journal of organic chemistry
سال انتشار:
2011
تعداد صفحات انگليسي
:
7
نوع فایل های ضمیمه :
Pdf+Word
حجم فایل :
999 Kb
کلمه عبور همه فایلها :
www.daneshgahi.com
عنوان انگليسي
:
Synthesis of Buprenorphine from Oripavine via N-Demethylation of Oripavine Quaternary Salts
چکیده
Abstract
Buprenorphine was synthesized from oripavine by a sequence involving the conversion of oripavine into its cyclopropylmethyl quaternary salt, N-demethylation with thiolate toN-cyclopropylmethyl nororipavine, and conversion of this material to the title compound by previously available methods. The new synthesis avoids toxic reagents used previously, is shorter, and proceeds in comparable yields. Experimental and spectral data are provided for all new compounds.
Keywords:
Buprenorphine